I don't think so, because in Naruto, from the beginning, Sasuke and Naruto were projected as rivals..... Now, Zoro doesn't view Luffy as his rival, and moreover, he is extremely loyal to Luffy(Remember that scene from Killer Bark arc when he almost sacrificed his life?), and his goal is to become the world's greatest swordsman, and that isn't hindered by the path that Luffy takes...... Whereas, Sasuke, is someone who uses hatred and vengeance as his strength, and moreover, one of the main sub-plots of Naruto is Naruto trying to bring Sasuke back..... So, if at all Zoro defects from the crew and becomes an antagonist of sorts, it would need an exceptionally strong reason.......