Things sadder than death that can happens to anime characters

[Blackangel]

is there anything like that? i am sure there are many things like losing family and all
so, is there anything like that?

 

[Burnsy]

In the end of Mawaru penguindrum, the three siblings lost their memories of each other in the process of stopping something worse and that's how the anime ends.

 

[Blackangel]

In the end of Mawaru penguindrum, the three siblings lost their memories of each other in the process of stopping something worse and that's how the anime ends.

that's something and i haven't really thought of it from before but i need to watch it
it's in my watchlist but not recently.