Has there ever been an anime in which the differences between anime characters ...

[Blackangel]

has there ever been an anime in which the differences between anime characters and "ordinary humans" are mentioned?
like it can be anything or a situation handling too lol

 

[Star_Of_Hope]

I didn't get this.
Most of the time in Shonen anime, you don't see anything relevant to real life and in Slice of life, that's just the opposite.

 

[Blackangel]

lol may be i am sure
but just asking to see if there are any other opinions and in anime anything is possible.